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Modeling Dynamic Regulatory Processes in Stroke

Posted by Bob Armstrong on December 1, 2012 4:50 PM EST
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I ran across this interesting paper (full and free access here) regarding building a dynamic model to represent the treatment of stroke victims following their immediate stabilization.  journal.pcbi.1002722.g008.png

Strokes are interesting things, namely because (in many cases) the impacts associated with stroke can be lessened or mitigated if the appropriate treatment is administered to the patient.

From the paper:

In this paper we describe an approach for in silico examination of responses of the blood transcriptome to neuroprotective agents and subsequent stroke through the development of dynamic models of the regulatory processes observed in the experimental gene expression data.

And, from MedicalExpress.com: 

The ability to examine strokes and other biological processes, through the use of computer simulations rather than after the fact on actual organisms, may significantly accelerate how quickly discoveries can be made in fighting diseases. The ability to model and simulate different treatments prior to administering them to a patient can help predict with more certainty which therapeutic approaches may be the most effective.

Access the paper here.

 

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